Реакция #2037751

Уравнение реакции

pivalic acid (R)-6-{2-[(3-fluoro-4-hydroxybenzoyl)isopropylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester

1-(7-azabicyclo[2.2.1]hept-7-yl)-2-bromoethanone

→

title compound

Выход 65.3%

(R)-6-{2-{{4-[2-(7-Azabicyclo[2.2.1]hept-7-yl)-ethoxy]-3-fluorobenzyl}isopropylamino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol

Выход 65.3%

Условия реакции

Обработка

1. 1
   Другоеpurified by LC-MS

Методика

Synthesized from pivalic acid (R)-6-{2-[(3-fluoro-4-hydroxybenzoyl)isopropylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (19 mg) and 1-(7-azabicyclo[2.2.1]hept-7-yl)-2-bromoethanone (15 mg) according to an analogous synthetic method to Example 404 and purified by LC-MS, the title compound (13 mg) was obtained.

Источник