Реакция #2028892

Уравнение реакции

compound

4-[4-bromomethyl-5-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide

collidine

dimethyl sulfoxide

→

desired product

Выход 66.0%

4-[4-formyl-5-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide

Выход 66.0%

Условия реакции

Обработка

1. 1
   ДругоеThe reaction solution was partitioned between ethyl acetate and water
2. 2
   Промывкаthe organic solution was washed with water
3. 3
   Другоеdried
4. 4
   Концентрированиеconcentrated
5. 5
   ДругоеThe residue was chromatographed (1:1 hexane:ethyl acetate)

Методика

To a solution of the compound prepared in Step 1 (362 mg, 0.79 mmol) in dimethyl sulfoxide (7 mL) was added collidine (0.14 mL, 1.0 mmol). The solution was heated at 120° C. for 3 hours and then kept at overnight at room temperature. The reaction solution was partitioned between ethyl acetate and water and the organic solution was washed with water, dried and concentrated. The residue was chromatographed (1:1 hexane:ethyl acetate) to give the desired product (205 mg, 66%).

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