Реакция #2028887

Уравнение реакции

hydrochloric acid

Ethyl formate

4′-chloroacetophenone

Sodium methoxide

→

yellow oil

Выход 100.2%

3-[4-(chloro)phenyl]-propane-1,3-dione

Выход 100.2%

Растворители

ether

Условия реакции

Обработка

1. 1
   ДругоеThe phases were separated
2. 2
   Промывкаthe ethereal solution washed with brine
3. 3
   Сушкаdried over magnesium sulfate
4. 4
   Фильтрацияfiltered
5. 5
   Концентрированиеconcentrated in vacuo

Методика

Ethyl formate (8.15 g, 0.11 mol) and 4′-chloroacetophenone (15.4 g, 0.1 mol) were stirred in ether (150 mL) at room temperature. Sodium methoxide (25%) (23.77 g, 0.11 mol) was added dropwise. The mixture was stirred at room temperature for 16 hours and was then treated with 150 mL of 1N hydrochloric acid. The phases were separated and the ethereal solution washed with brine, dried over magnesium sulfate, filtered and concentrated in vacuo to afford 18.3 g of a yellow oil. The resulting crude mixture was used directly in the next step without purification.

Источник