Реакция #2028884

Уравнение реакции

HCl

sodium methoxide

Ethyl trifluoroacetate

6-methyltetralone

→

oil

Выход 85.1%

6-methyl-2-(trifluoroacetyl)tetralone

Выход 85.1%

Растворители

ether

Условия реакции

Обработка

1. 1
   ДругоеThe organic layer was collected
2. 2
   Промывкаwashed with brine
3. 3
   Сушкаdried over MgSO4
4. 4
   Концентрированиеconcentrated in vacuo

Методика

Ethyl trifluoroacetate (5.33 g, 37.5 mmol) was dissolved in ether (50 mL) and treated with a sodium methoxide solution (25% in methanol, 9.92 g, 45.9 mmol) followed by 6-methyltetralone (5.94 g, 37.1 mmol). The reaction was stirred at room temperature for 6.1 hours then treated with 1N HCl (20 mL). The organic layer was collected, washed with brine, dried over MgSO4, and concentrated in vacuo to give a brown oil (8.09 g) that was used in the next step without further purification.

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