Реакция #2021478

Уравнение реакции

sodium acetate

2-(N-ethylanilino)ethyl acetate

phosphoryl chloride

→

2-(ethyl(4-formylphenyl)amino)ethyl acetate

Выход 84.2%

Растворители

dimethylformamide

dimethylformamide

Условия реакции

Обработка

1. 1
   Другоеto react for 6 hours at room temperature
2. 2
   ЭкстракцияAn organic layer was extracted with ethyl acetate

Методика

After adding 55.8 g of ice-cooled phosphoryl chloride to 26.6 g of dimethylformamide, a solution of 63.0 g of the 2-(N-ethylanilino)ethyl acetate in 40 ml of dimethylformamide was slowly added at room temperature, this was caused to react for 6 hours at room temperature while stirring, and then poured into an aqueous solution of 150 g of sodium acetate under ice cooling. An organic layer was extracted with ethyl acetate and the solvent was boiled off under reduced pressure. This was refined by silica gel column chromatography to yield 60.2 g of 2-(ethyl(4-formylphenyl)amino)ethyl acetate.

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