Реакция #2016172

Уравнение реакции

17

2,2-Dimethyl-propionic acid (3S,4S)-3-methyl-piperidin-4-yl ester

NaOH

→

2,2-Dimethyl-propionic acid (3R,4R)-3-methyl-piperidin-4-yl ester

Условия реакции

Обработка

1. 1
   Другоеto obtain the free base which
2. 2
   Другоеis then crystallized with D-(+)-O,O′-Dibenzoyl tartaric acid
3. 3
   Другоеto give the antipode 20

Методика

The mother liquor of 17 from above is treated with 1N-NaOH to obtain the free base which is then crystallized with D-(+)-O,O′-Dibenzoyl tartaric acid as described above to give the antipode 20.

Источник