Реакция #2016170

Уравнение реакции

trans-ester

trans-2,2-Dimethyl-propionic acid 1-benzyl-3-methyl-piperidin-4-yl ester

HCl

→

trans-2,2-dimethyl-propionic acid 3-methyl-piperidin-4-yl ester

Растворители

methanol

Условия реакции

Обработка

1. 1
   ФильтрацияThe mixture is filtered
2. 2
   Другоеevaporated
3. 3
   workup.DISSOLUTIONThe residue is redissolved in ether
4. 4
   Экстракцияextracted with 1N-NaOH and brine
5. 5
   ДругоеEvaporation
6. 6
   Другоеgives a colourless oil

Методика

The trans-ester 18 (104 g, 359 mmol) is hydrogenated in methanol (1700 ml) with Pd/C in the presence of one equivalent of HCl (431 ml, 359 mmol, 1.25M in MeOH). The mixture is filtered and evaporated. The residue is redissolved in ether and extracted with 1N-NaOH and brine. Evaporation gives a colourless oil.

Источник