Реакция #2012

Уравнение реакции

BOP

D-Homophenylalanine allyl ester

triethylamine

3-t-butoxycarbonylamino-3-methylbutanoic acid

→

desired product

Выход 59.7%

(R)-α-[(3-Benzyloxycarbonylamino-3-methyl-1-oxobutyl)amino]benzenebutanoic acid allyl ester

Выход 59.7%

Растворители

—

hexanes

methylene chloride

ethyl acetate

methylene chloride

Условия реакции

Обработка

1. 1
   Другоеto give a homogeneous solution
2. 2
   workup.STIRRINGthe reaction mixture stirred together at room temperature for 12 h
3. 3
   ДругоеThe reaction mixture was quenched
4. 4
   workup.ADDITIONby adding brine (10 ml)
5. 5
   Другоеdirectly to the reaction
6. 6
   Сушкаthe combined methylene chloride extracts dried with powdered anhydrous magnesium sulfate
7. 7
   Фильтрацияfiltered
8. 8
   Другоеevaporated under reduced pressure
9. 9
   ДругоеThe pale yellow oil thus obtained

Методика

D-Homophenylalanine allyl ester (350 mg; 1.60 mmol), triethylamine (445 μl; 3.19 mmol) and 3-t-butoxycarbonylamino-3-methylbutanoic acid (412.8 mg; 1.64 mmol) were dissolved in dry methylene chloride (3 ml) and stirred at room temperature to give a homogeneous solution. BOP was added to the solution over 5 minutes and the reaction mixture stirred together at room temperature for 12 h. The reaction mixture was quenched by adding brine (10 ml) directly to the reaction. The crude products were isolated by extraction with methylene chloride (2×25 ml); the combined methylene chloride extracts dried with powdered anhydrous magnesium sulfate, filtered and evaporated under reduced pressure. The pale yellow oil thus obtained was subjected to column chromatography on silica gel using an eluant of ethyl acetate and hexanes (1:1 v/v). In this way, 432 mg (59.7%) of the desired product was isolated as a colorless oil. FAB-MS: -calculated for C26H32N2O5 452.2; found 453.4 (M+1).

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