Реакция #2006426

Уравнение реакции

methyl iodide

compound 28

4-(Benzenesulfonylamino)-phenyl Iodide

K2CO3

→

title compound

Выход 196.6%

N-Methyl-4-iodophenylbenzenesulfonamide

Выход 196.6%

Растворители

DMF

Условия реакции

Обработка

1. 1
   ДругоеThe resulting reaction mixture
2. 2
   ДругоеThe solvent is then removed
3. 3
   workup.ADDITIONwater was added
4. 4
   ЭкстракцияThe resulting mixture was extracted with ethyl acetate
5. 5
   Другоеthe combined organic phases were dried
6. 6
   Концентрированиеconcentrated
7. 7
   ДругоеPurification by flash chromatography

Методика

To compound 28 (from Example 18) (500 mg, 1.39 mmol) in DMF (10 mL) were added at room temperature K2CO3 (962 mg, 6.96 mmol), followed by methyl iodide (395 mg, 2.78 mmol). The resulting reaction mixture was stirred at room temperature for 16 hours. The solvent is then removed and water was added. The resulting mixture was extracted with ethyl acetate, and the combined organic phases were dried and concentrated. Purification by flash chromatography using hexane:ethyl acetate (8:2) afforded 510 mg (98%) of the title compound as a white solid.

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