Реакция #2006423

Уравнение реакции

4-vinyl-benzoic acid

benzenethiol

VAZO

→

white solid

Выход 85.0%

4-(2-Thiophenyl)-ethyl Benzoic Acid

Выход 85.0%

Растворители

benzene

Условия реакции

Обработка

1. 1
   ДругоеAccording to the published procedure (Gareau et al., Tet. Lett., 1994, 1837), under nitrogen atmosphere in a 50 mL round bottomed flask
2. 2
   Температураat reflux
3. 3
   Другоеthe solvent was evaporated under vacuo
4. 4
   ДругоеThe solid was purified by trituration

Методика

According to the published procedure (Gareau et al., Tet. Lett., 1994, 1837), under nitrogen atmosphere in a 50 mL round bottomed flask containing 4-vinyl-benzoic acid (1.0 g, 6.75 mmoles) in 10 mL of benzene (0.7 M) was added benzenethiol (797 μL, 7.76 mmoles) followed by VAZO™ (Aldrich Chemical Company, 495 mg, 2.02 mmoles). The mixture was stirred for 12 hours at reflux. The resulting solution was cooled at room temperature and the solvent was evaporated under vacuo. The solid was purified by trituration using hexane and dichloromethane to afford 1.94 g (85%) of white solid.

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