Реакция #1995871

Уравнение реакции

benzaldehyde methylhydrazone

ethyl 2-ethoxymethylene-4,4-difluoro-3-oxo-butyrate

→

product

Выход 74.1%

Ethyl 4,4-difluoro-2-[1-{N-methyl-N′-[1-phenylmethylidene]hydrazino}-methylidene]-3-oxobutyrate

Выход 74.1%

Растворители

toluene

Условия реакции

Обработка

1. 1
   Другоеas a result of which the internal temperature
2. 2
   Другоеrose to 35° C
3. 3
   Температураat reflux temperature for 1.25 hours
4. 4
   workup.STIRRINGstirred at 25° C. for 15 hours
5. 5
   ФильтрацияThe precipitated solid was filtered off with a suction
6. 6
   Фильтрацияfilter
7. 7
   Промывкаwashed twice with 25 m
8. 8
   ДругоеAfter drying at 40-50° C. under reduced pressure

Методика

13.8 g (0.1 mol) of benzaldehyde methylhydrazone and 62.2 g of toluene were admixed with 23.7 g (0.1 mol) of ethyl 2-ethoxymethylene-4,4-difluoro-3-oxo-butyrate, as a result of which the internal temperature rose to 35° C. The reaction mixture was stirred at reflux temperature for 1.25 hours and then stirred at 25° C. for 15 hours. The precipitated solid was filtered off with a suction filter and washed twice with 25 m; each time of toluene. After drying at 40-50° C. under reduced pressure, 23 g of product were obtained.

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