Реакция #1994258

Уравнение реакции

10-(biphenyl-4-yl)-9,10-dihydroacridine

bromosuccinimide

→

10-(biphenyl-4-yl)-2-bromo-9,10-dihydroacridine

Выход 77.7%

Растворители

chloroform

Условия реакции

Обработка

1. 1
   Промывкаthe resultant solution was washed with distilled water
2. 2
   ЭкстракцияThen, an organic layer was extracted
3. 3
   Сушкаdried with sodium sulfate so as
4. 4
   Другоеto remove the solvent
5. 5
   ДругоеThe residue was purified by silica gel column chromatography (methylene chloride/n-hexane (1/20))

Методика

The obtained 10-(biphenyl-4-yl)-9,10-dihydroacridine (15.3 g, 45.9 mmol) was added with chloroform (500 ml), and then with bromosuccinimide (9.8 g, 55.1 mmol). The resultant solution was stirred at room temperature for 2 hours. After the reaction was completed, the resultant solution was washed with distilled water. Then, an organic layer was extracted and dried with sodium sulfate so as to remove the solvent. The residue was purified by silica gel column chromatography (methylene chloride/n-hexane (1/20)) to obtain 10-(biphenyl-4-yl)-2-bromo-9,10-dihydroacridine compound (white solid, 14.7 g, yield 77%).

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