Реакция #1994240

ord-18f9c90d2443485eb7e9a4759defbe40

Уравнение реакции

Br.COc1ccc2c(c1)[C@]13CCCC[C@@H]1[C@H](C2)N(C)CC3
dextromethorphan HBr
→
COc1ccc2c(c1)[C@]13CCCC[C@@H]1[C@H](C2)N(C)CC3
Dextromethorphan

Реактанты

Br.COc1ccc2c(c1)[C@]13CCCC[C@@H]1[C@H](C2)N(C)CC3
dextromethorphan HBr

Реагенты

Нет

Растворители

O
water

Условия реакции

Температура
77.5°CELSIUS
Подробные условия
See reaction.notes.procedure_details.

Обработка

  1. 1
    workup.ADDITIONfollowed by the addition of 223.01 g AMBERLITE IRP-69 resin
  2. 2
    workup.ADDITIONunder gentle mixing for 4 hours
  3. 3
    Другоеwas then decanted
  4. 4
    Промывкаrinsed with purified water twice
  5. 5
    Другоеdried in an oven
  6. 6
    Температураmaintained at 50° C. until the moisture content
  7. 7
    Фильтрацияsieved through a 40 mesh screen

Методика

Uncoated Dextromethorphan Resin Complex was prepared by first dissolving 119.28 g of dextromethorphan HBr in 1 L of purified water heated to 75-80° C., followed by the addition of 223.01 g AMBERLITE IRP-69 resin under gentle mixing for 4 hours. At the completion, the suspension was allowed to settle, and was then decanted and rinsed with purified water twice and dried in an oven maintained at 50° C. until the moisture content was around 5%. The dried resin complex was hand sieved through a 40 mesh screen.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US08597684B2uspto-grants-2013_12