Реакция #1994226

Уравнение реакции

Boc-Gly Rotigotine HCl

trifluoroacetic acid

→

Gly Rotigotine

Выход 79.0%

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   Другоеall the volatiles were removed
2. 2
   Другоеa rotary evaporator
3. 3
   workup.DISSOLUTIONThe residue (dark yellow) was dissolved in methanol
4. 4
   Другоеprecipitated
5. 5
   workup.ADDITIONby adding into diethyl ether (40 mL)
6. 6
   ФильтрацияThe pale yellow precipitate was filtered
7. 7
   Другоеdried

Методика

The Boc-Gly-Rotigotine HCl was deprotected by first dissolving the product (1.258 g, 2.55 mmol) in dichloromethane (64 ml). After addition of trifluoroacetic acid (9.83 ml, 128 mmol), the reaction mixture was stirred for 1 hour at room temperature and then all the volatiles were removed using a rotary evaporator. The residue (dark yellow) was dissolved in methanol and precipitated by adding into diethyl ether (40 mL). The pale yellow precipitate was filtered using a glass frit and dried to give Gly-Rotigotine.2TFA (1.140 g, 79% yield).

Источник