Реакция #1985

Уравнение реакции

compound

1-benzyl-3-trifluoromethylpyrrolidine-3-carboxylic acid

LAH

→

title compound

Выход 99.9%

1-benzyl-3-trifluoromethylpyrrolidine-3-methanol

Выход 99.9%

Растворители

THF

Условия реакции

Обработка

1. 1
   ДругоеThe reaction was quenched by the sequential dropwise addition of 0.35 mL water, 0.35 mL of 15% NaOH and 1.3 mL of water
2. 2
   workup.STIRRINGthe mixture was stirred for 1 hour
3. 3
   Фильтрацияfiltered
4. 4
   ДругоеThe filtrate was dried
5. 5
   Концентрированиеconcentrated

Методика

The compound from step 456a (2.32 g) was dissolved in 60 mL of dry THF, 1.12 eq of LAH (1N in dry THF) was added, and the reaction was stirred under N2 for 3 hours. The reaction was quenched by the sequential dropwise addition of 0.35 mL water, 0.35 mL of 15% NaOH and 1.3 mL of water, then the mixture was stirred for 1 hour and filtered. The filtrate was dried and concentrated to give 2.2 g of the title compound.

Источник