Реакция #1973986

Уравнение реакции

5-Bromoindoline

sodium hydride

Methanesulfonyl chloride

→

title compound

Выход 61.0%

5-bromo-1-(methylsulfonyl)indoline

Выход 61.0%

Растворители

DMF

Условия реакции

Обработка

1. 1
   workup.STIRRINGthe solution was stirred at room temperature for 30 min
2. 2
   workup.STIRRINGthe solution stirred at room temperature overnight
3. 3
   Концентрированиеconcentrated in vacuo
4. 4
   ДругоеThe crude product was purified by column chromatography on silica gel eluting with 2% CH3OH/CHCl3

Методика

To DMF (5.0 ml) was added sodium hydride (53 mg, 1.3 mmol) and the solution stirred at room temperature for 30 min. 5-Bromoindoline (240 mg, 1.2 mmol) was added and the solution was stirred at room temperature for 30 min. Methanesulfonyl chloride (94 ul, 1.2 mmol) was added and the solution stirred at room temperature overnight, then concentrated in vacuo. The crude product was purified by column chromatography on silica gel eluting with 2% CH3OH/CHCl3 to give the title compound (202 mg, 60%).

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