Реакция #1973974

Уравнение реакции

ethyl thioglycolate

4-bromo-2-fluorobenzaldehyde

triethylamine

→

title compound

Выход 92.0%

ethyl 6-bromobenzo[b]thiophene-2-carboxylate

Выход 92.0%

Растворители

DMSO

Условия реакции

Обработка

1. 1
   ДругоеThe mixture was partitioned between H2O (50 mL) and CH2Cl2 (2×50 mL)
2. 2
   Сушкаthe combined organic layers were dried over Na2SO4
3. 3
   ФильтрацияThe drying agent was filtered off
4. 4
   Другоеthe solvent was removed in vacuo

Методика

A solution of ethyl thioglycolate (0.65 g, 5.42 mmol), 4-bromo-2-fluorobenzaldehyde (1.0 g, 4.93 mmol) and triethylamine (1.25 mL, 12.3 mmol) in DMSO (5 mL) was heated at 75° C. for 2 h. The mixture was partitioned between H2O (50 mL) and CH2Cl2 (2×50 mL), and the combined organic layers were dried over Na2SO4. The drying agent was filtered off, and the solvent was removed in vacuo to give the title compound as an oil (1.29 g, 92%).

Источник