Реакция #1973973

Уравнение реакции

methyl 4-bromo-2-(bromomethyl)benzoate

(2,4-dimethoxyphenyl)methanamine

triethylamine

→

title compound

Выход 44.2%

5-bromo-2-(2,4-dimethoxybenzyl)isoindolin-1-one

Выход 44.2%

Растворители

THF

Условия реакции

Обработка

1. 1
   ФильтрацияThe resulting solid was filtered off
2. 2
   Концентрированиеthe filtrate was concentrated in vacuo
3. 3
   ДругоеThe crude product was purified by column chromatography on silica gel using 1:4 EtOAc

Методика

To a solution of methyl 4-bromo-2-(bromomethyl)benzoate (1.0 g, 3.25 mmol) and (2,4-dimethoxyphenyl)methanamine (0.65 g, 3.90 mmol) in THF (16 mL) was added triethylamine (0.91 mL, 6.5 mmol), and the resulting mixture was stirred at room temperature for 16 h. The resulting solid was filtered off, and the filtrate was concentrated in vacuo. The crude product was purified by column chromatography on silica gel using 1:4 EtOAc:hexanes as the eluent to give the title compound as a colorless solid (0.52 g, 44%).

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