Реакция #1973967

Уравнение реакции

2-hydroxy-3,5-diiodobenzoic acid

dimethyl sulfate

acetone

→

solid

methyl 3,5-diiodo-2-methoxybenzoate

Условия реакции

Обработка

1. 1
   Температураwas heated
2. 2
   Температураat reflux for 16 h
3. 3
   Температураcooled
4. 4
   Концентрированиеconcentrated
5. 5
   workup.DISSOLUTIONThe residue was dissolved in EtOAc
6. 6
   Промывкаwashed with water, brine
7. 7
   Сушкаdried (Na2SO4)
8. 8
   Фильтрацияfiltered
9. 9
   Концентрированиеconcentrated

Методика

A mixture of 2-hydroxy-3,5-diiodobenzoic acid (3.9 g, 10.0 mmol) potassium carbonate (4.15 g, 30.0 mmol) and dimethyl sulfate (2.77 g, 22.0 mmol) in acetone (33 ml) was heated at reflux for 16 h, cooled and concentrated. The residue was dissolved in EtOAc and washed with water, brine, dried (Na2SO4), filtered and concentrated to give an off-white solid (4.2 g, quantitative yield).

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