Реакция #1973962

Уравнение реакции

product

methyl 3-tert-butyl-2-hydroxy-5-nitrobenzoate

toluene

acrylic acid

acrylic acid

→

crude title compound

3-(3-tert-butyl-4-methoxy-5-(methoxycarbonyl)phenylamino) propanoic acid

Условия реакции

Обработка

1. 1
   ТемператураThis mixture was heated
2. 2
   Температураto reflux
3. 3
   workup.ADDITIONadded every 3 h
4. 4
   ТемператураThe mixture was then refluxed for 24 h
5. 5
   ТемператураThe mixture was then cooled
6. 6
   Концентрированиеconcentrated under vacuum to dryness

Методика

The product from Example 5, Part C (16.44 g, 69.3 mmol) was dissolved in toluene (200 mL). This mixture was heated to reflux and acrylic acid added over time (1 mL of acrylic acid added every 3 h, 5.23 mL total, 76.2 mmol). The mixture was then refluxed for 24 h. The mixture was then cooled and concentrated under vacuum to dryness to yield an oil as the crude title compound that was used directly in the next reaction.

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