Реакция #1973946

Уравнение реакции

triethylamine

methacrylic acid chloride

6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol

→

6,7,8,9-tetrahydro-5H-benzocyclohepten-5-yl methacrylate

Растворители

toluene

Условия реакции

Обработка

1. 1
   workup.STIRRINGThe mixture was stirred at room temperature for 16 hours
2. 2
   workup.DISTILLATIONBy standard aqueous work-up and solvent distillation
3. 3
   Другоеa crude product was obtained
4. 4
   ДругоеIt was purified by column chromatography

Методика

With stirring and ice cooling, 111 g of triethylamine was added to a mixture of 120 g of methacrylic acid chloride, 240 g of 6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol, and 1500 g of toluene. The mixture was stirred at room temperature for 16 hours. By standard aqueous work-up and solvent distillation, a crude product was obtained. It was purified by column chromatography, yielding the target compound, 6,7,8,9-tetrahydro-5H-benzocyclohepten-5-yl methacrylate.

Источник