Реакция #1960525

ord-83e2860a1c0941d3a6e18ab365509ab4

Уравнение реакции

Cl
HCl
N=C(N)NCCC[C@H](N)C(=O)O
arginine
CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(CSc3nc(=O)c(O)nn3C)CS[C@H]12)c1csc(N)n1.N=C(N)NCCC[C@H](N)C(=O)O
ceftriaxone
CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(CSc3nc(=O)c(O)nn3C)CS[C@H]12)c1csc(N)n1.N=C(N)NCCC[C@H](N)C(=O)O
ceftriaxone arginine
NCCCC[C@H](N)C(=O)O
lysine
CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(CSc3nc(=O)c(O)nn3C)CS[C@H]12)c1csc(N)n1
ceftriaxone
NCCCC[C@H](N)C(=O)O
lysine
CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(CSc3nc(=O)c(O)nn3C)CS[C@H]12)c1csc(N)n1.NCCCC[C@H](N)C(=O)O
ceftriaxone lysine

Растворители

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Методика

About 610 mg (3.34 mole) of lysine was dissolved in 50 ml of distilled water. Additionally, 1.0 gram (1.67 mole) of ceftriaxone was dissolved in 50 ml of a separate volume of distilled water. The solution containing arginine was adjusted with 1N—HCl until the solution reached pH 6.0. The ceftriaxone solution was then added to the lysine solution and stirred by a magnetic stirrer at room temperature for 1 hour forming a ceftriaxone-lysine solution. To the ceftriaxone-lysine solution was added about 400 mg of carrageenan and the solution was stirred by magnetic stirrer at room temperature for 2 hours. A ceftriaxone-lysine-carrageenan hydrogel was formed. The hydrogel was then freeze-dried while in the swollen state, yielding about 1.92 g of the freeze-dried complex.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US08303989B2uspto-grants-2012_11