Реакция #1960521

Уравнение реакции

Salicylaldehyde

pyridine

bromoacetyl bromide

→

bromo-acetic acid 2-formyl-phenyl ester

Выход 60.3%

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   ПромывкаThe reaction mixture was washed with 1000 ml of water and 1500 ml of 5% sodium bicarbonate solution
2. 2
   Сушкаdried over sodium sulphate
3. 3
   workup.DISTILLATIONfollowed by distillation of solvent under reduced pressure

Методика

To a solution of Salicylaldehyde (50 grams) and pyridine (48.5 grams) in dichloromethane (500 ml) maintained at 0-5° C. under nitrogen atmosphere was added dropwise bromoacetyl bromide (210.6 grams). The reaction mixture was stirred for one hour at the same temperature. The reaction mixture was washed with 1000 ml of water and 1500 ml of 5% sodium bicarbonate solution, dried over sodium sulphate followed by distillation of solvent under reduced pressure to get 60.0 grams of bromo-acetic acid 2-formyl-phenyl ester.

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