Реакция #1960508

Уравнение реакции

8-ethoxy-5,6-difluoro-3-(4-propylcyclohexyl)-3H-benzo[f]chromene

→

8-ethoxy-5,6-difluoro-3-(4-propylcyclohexyl)-2,3-dihydro-1H-benzo[f]chromene

Растворители

THF

Условия реакции

Обработка

1. 1
   ФильтрацияThe reaction solution is filtered
2. 2
   Другоеthe filtrate is evaporated to dryness
3. 3
   ДругоеThe residue is recrystallised from ethyl acetate

Методика

5.1 g (13.1 mmol) of 8-ethoxy-5,6-difluoro-3-(4-propylcyclohexyl)-3H-benzo[f]chromene are hydrogenated at atmospheric pressure in THF and in the presence of Pd/C (5% of Pd). The reaction solution is filtered, and the filtrate is evaporated to dryness. The residue is recrystallised from ethyl acetate, giving 8-ethoxy-5,6-difluoro-3-(4-propylcyclohexyl)-2,3-dihydro-1H-benzo[f]chromene as a colourless solid (m.p. 158° C.).

Источник