Реакция #1960484

Уравнение реакции

2,3-difluorophenol

propargyl bromide

potassium carbonate

→

1,2-difluoro-3-prop-2-ynyloxybenzene

Растворители

ethyl methyl ketone

Условия реакции

Обработка

1. 1
   ФильтрацияThe batch is filtered
2. 2
   Промывкаthe filter residue is washed with MTBE
3. 3
   ДругоеThe filtrate is evaporated to dryness
4. 4
   Другоеthe residue is purified by column chromatography (SiO2, n-heptane:MTBE=3:1)

Методика

115.0 g (0.88 mol) of 2,3-difluorophenol are refluxed for 3 h in 1.6 l of ethyl methyl ketone together with 118.2 ml (17.7 mol) of propargyl bromide (80% soln. in toluene) and 146.6 g (138.2 mol) of potassium carbonate. The batch is filtered, and the filter residue is washed with MTBE. The filtrate is evaporated to dryness, and the residue is purified by column chromatography (SiO2, n-heptane:MTBE=3:1).

Источник