Реакция #1958050

Уравнение реакции

8-methyl-3-(4-methylphenyl)-8-azabicyclo[3.2.1]octan-3-ol

acetic acid

hydrochloric acid

fumaric acid

→

title compound

(±)-8-Methyl-3-(4-methylphenyl)-8-azabicyclo[3.2.1]oct-2-ene Fumarate

Растворители

diethyl ether

methanol

Условия реакции

Обработка

1. 1
   КонцентрированиеThe resulting solution was concentrated to dryness
2. 2
   Другоеthe title compound precipitated as powder
3. 3
   Другоеwas isolated by filtration

Методика

The title compound was prepared from 8-methyl-3-(4-methylphenyl)-8-azabicyclo[3.2.1]octan-3-ol (3.4 g, 14.7 mmol), glacial acetic acid (11 mL) and concentrated hydrochloric acid (11 mL). The free base of the title compound was dissolved in diethyl ether and added fumaric acid (1.3 g, 11.2 mmol) in methanol. The resulting solution was concentrated to dryness, the residue was trituated in diethyl ether, the title compound precipitated as powder and was isolated by filtration. Yield 2.46 g (51%) m.p. 156.8-157.4° C.

Источник