Реакция #1929062

Уравнение реакции

HCl

potassium hydrogen carbonate

6-(chloracetamido) hexanoic acid

potassium cyanide

→

6-(cyanacetamido)hexanoic acid

Растворители

water

Условия реакции

Обработка

1. 1
   Температураwas cooled on ice
2. 2
   ЭкстракцияThe residue after extraction
3. 3
   Другоеwas purified by chromatography (silica gel, solvent: ethyl acetate)

Методика

2.8 g (20 mMol) potassium hydrogen carbonate was added to 8.3 g (40 mMol) 6-(chloracetamido) hexanoic acid dissolved in 25 ml water. 3.2 g (48 mMol) potassium cyanide was then added to the clear solution which was cooled on ice. The reaction mixture was stirred for 17 hours and was then acidified with HCl (2 N). The residue after extraction was purified by chromatography (silica gel, solvent: ethyl acetate).

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