Реакция #1929004

Уравнение реакции

compound ( 48 )

4-bromo-1-[5-(trifluoromethyl)-2-pyridyl]piperidine

sodium hydride

DMF

compound ( 46 )

2-propoxy-4-(trifluoromethyl)benzenethiol

→

4-[2-propoxy-4-(trifluoromethyl)phenylsulfanyl]-1-[5-(trifluoromethyl)-2-pyridyl]piperidine

Растворители

water

Условия реакции

Обработка

1. 1
   Температураwas heated to 100° C.
2. 2
   workup.STIRRINGwas then stirred for 1 hour
3. 3
   ТемператураAfter the mixture was cooled
4. 4
   Экстракцияwas then subjected to extraction with ethyl acetate
5. 5
   ПромывкаAfter its organic layer was washed with water
6. 6
   Сушкаwas then dried with anhydrous magnesium sulfate, it
7. 7
   Фильтрацияwas filtered
8. 8
   Концентрированиеwas then concentrated under reduced pressure
9. 9
   ДругоеIts residue was purified by column chromatography
10. 10
    Другоеto produce the chemical compound

Методика

After 60% sodium hydride was added, with chilling on ice, to the DMF (7 ml) solution of the chemical compound (46) (0.62 g), it was warmed to room temperature, and was then stirred for 30 minutes. After the chemical compound (48) (0.74 g) was added to the mixture, it was heated to 100° C., and was then stirred for 1 hour. After the mixture was cooled, it was poured into water, and was then subjected to extraction with ethyl acetate. After its organic layer was washed with water, and was then dried with anhydrous magnesium sulfate, it was filtered, and was then concentrated under reduced pressure. Its residue was purified by column chromatography to produce the chemical compound mentioned in the above title (0.90 g).

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