Реакция #1927

Уравнение реакции

methyl 3-bromomethyl-2-thiophenecarboxylate

triphenylphosphine

→

2-methoxycarbonylthiophen-3-ylmethyltriphenylphosphonium bromide

Выход 70.4%

Растворители

toluene

Условия реакции

Обработка

1. 1
   ФильтрацияThe precipitated crystals were collected by filtration
2. 2
   Другоеdried

Методика

To a solution of methyl 3-bromomethyl-2-thiophenecarboxylate (7.31 g, 31.1 mmol) in toluene (90 ml) was added triphenylphosphine (7.92 g, 30.2 mmol) under ice cooling. The temperature of the mixture was raised to room temperature, followed by stirring for 2 days. The precipitated crystals were collected by filtration and dried to give 2-methoxycarbonylthiophen-3-ylmethyltriphenylphosphonium bromide (10.57 g, 70.4%). This product was subjected to the reaction of Reference Example 13 without purification.

Источник