Реакция #1921385

ord-ff14b111691848efa48514ca086cf2b8

Уравнение реакции

C[C@H](CCCC(C)(C)OC(=O)c1ccccc1)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](OC(=O)c5ccccc5)CC[C@]4(C)[C@H]3CC[C@]12C
3β,25-dibenzoyloxycholest- 5-ene
CC1(C)C(=O)N(Br)C(=O)N1Br
dibromo-dimethylhydantoin
→
C[C@H](CCCC(C)(C)OC(=O)c1ccccc1)[C@H]1CC[C@H]2[C@@H]3C(Br)C=C4C[C@@H](OC(=O)c5ccccc5)CC[C@]4(C)[C@H]3CC[C@]12C
title product
C[C@H](CCCC(C)(C)OC(=O)c1ccccc1)[C@H]1CC[C@H]2[C@@H]3C(Br)C=C4C[C@@H](OC(=O)c5ccccc5)CC[C@]4(C)[C@H]3CC[C@]12C
7-Bromo-3 β,25-dibenzoyloxycholest-5-ene

Реактанты

C[C@H](CCCC(C)(C)OC(=O)c1ccccc1)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](OC(=O)c5ccccc5)CC[C@]4(C)[C@H]3CC[C@]12C
3β,25-dibenzoyloxycholest- 5-ene
CC1(C)C(=O)N(Br)C(=O)N1Br
dibromo-dimethylhydantoin

Реагенты

Нет

Растворители

CCCCCC
hexane

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Обработка

  1. 1
    ТемператураReflux for 30 minutes
  2. 2
    Фильтрацияfilter
  3. 3
    Промывкаwash with 2 ml
  4. 4
    КонцентрированиеConcentrate the combined filtrate to dryness

Методика

To a boiling solution of 2.02 gm. of 3β,25-dibenzoyloxycholest- 5-ene (3.3 mmole) in 90 ml. of hexane, and 720 mg. (2.52 mmole) of dibromo-dimethylhydantoin. Reflux for 30 minutes, cool to room temperature, filter and wash with 2 ml. of carbontetrachloride. Concentrate the combined filtrate to dryness to obtain the title product. (2.3 gm.)

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US04069321uspto-grants-1978_01