Реакция #1914823

Уравнение реакции

16-hydroxyhexadecanoic acid

HBr

→

desired product

Выход 99.0%

16-Bromohexadecanoic acid

Выход 99.0%

Растворители

acetic acid

Условия реакции

Обработка

1. 1
   Другое16-Bromohexadecanoic acid was prepared
2. 2
   ТемператураUpon cooling
3. 3
   ФильтрацияIt was filtered out
4. 4
   Промывкаwashed with 3×100 ml of cold water
5. 5
   ДругоеMaterial was purified by recrystalization from n-hexane
6. 6
   Фильтрацияfiltered out
7. 7
   Другоеdried on high vacuum

Методика

16-Bromohexadecanoic acid was prepared by refluxing for 48 hrs 5.0 gr (18.35 mmole) of 16-hydroxyhexadecanoic acid in 24 ml of 1:1 v/v mixture of HBr (48% aqueous solution) and glacial acetic acid. Upon cooling, crude product was solidified inside the reaction vessel. It was filtered out and washed with 3×100 ml of cold water. Material was purified by recrystalization from n-hexane, filtered out and dried on high vacuum. 6.1 gr (99% yield) of the desired product were obtained.

Источник