Реакция #1909783

Уравнение реакции

1-tert-butoxycarbonyl-4-ethylisonipecotic acid ethyl ester

lithium hydroxide

→

title compound

Выход 45.3%

1-tert-Butoxycarbonyl-4-ethylisonipecotic acid

Выход 45.3%

Растворители

ethanol

Условия реакции

Обработка

1. 1
   Температураthe mixture was refluxed
2. 2
   Температураunder heating for 20 hours
3. 3
   КонцентрированиеThen, the reaction mixture was concentrated
4. 4
   workup.ADDITIONwater was added to the residue
5. 5
   ПромывкаThe aqueous layer was washed with ether
6. 6
   Экстракцияextracted with ether
7. 7
   СушкаThe organic layer was dried over anhydrous magnesium sulfate
8. 8
   Концентрированиеconcentrated under reduced pressure

Методика

To a solution of 1-tert-butoxycarbonyl-4-ethylisonipecotic acid ethyl ester (570 mg) in ethanol (10 ml) was added a 1M lithium hydroxide solution (8 ml), and the mixture was refluxed under heating for 20 hours. Then, the reaction mixture was concentrated, and water was added to the residue. The aqueous layer was washed with ether acidified with 1N hydrochloric acid, and extracted with ether. The organic layer was dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give the title compound (233 mg, yield 45%).

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