Реакция #1902012

Уравнение реакции

compound

2-(2-Propoxyphenyl)-5-methyl-7-cyclopentyl-3H -imidazo[5,1-f][1,2,4]-triazin-4-one

nitric acid

→

5-Nitro-2-propoxyphenyl-5-methyl-7-cyclopentyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-one

Растворители

trifluoroacetic acid

Условия реакции

Обработка

1. 1
   ДругоеThe product is purified by silica gel chromatography

Методика

Analogously to the procedure of example 41A, 10.0 g (28.4 mmol) of the compound from example 26A are nitrated in 160 ml of trifluoroacetic acid and 40 ml of 70% strength nitric acid. The product is purified by silica gel chromatography using toluene and ethyl acetate in a gradient system.

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