Реакция #1896493

Уравнение реакции

methyl chloroformate

(S)-2-amino-2-(tetrahydro-2H-pyran-4-yl)acetic acid

sodium carbonate

→

(S)-2-(Methoxycarbonylamino)-2-(tetrahydro-2H-pyran-4-yl)acetic acid

Растворители

water

Условия реакции

Обработка

1. 1
   Другоеthaw to ambient temperature
2. 2
   ДругоеThe reaction mixture was then partitioned between 1N HCl and ethyl acetate
3. 3
   ДругоеThe organic layer was removed
4. 4
   Экстракцияthe aqueous layer was further extracted with 2 additional portions of ethyl acetate
5. 5
   ПромывкаThe combined organic layers were washed with brine
6. 6
   Сушкаdried over magnesium sulfate
7. 7
   Фильтрацияfiltered
8. 8
   Концентрированиеconcentrated in vacuo
9. 9
   Другоеto afford Cap-170a colorless residue

Методика

To (S)-2-amino-2-(tetrahydro-2H-pyran-4-yl)acetic acid (505 mg; 3.18 mmol; obtained from Astatech) in water (15 ml) was added sodium carbonate (673 mg; 6.35 mmol), and the resultant mixture was cooled to 0° C. and then methyl chloroformate (0.26 ml; 3.33 mmol) was added dropwise over 5 minutes. The reaction was allowed to stir for 18 hours while allowing the bath to thaw to ambient temperature. The reaction mixture was then partitioned between 1N HCl and ethyl acetate. The organic layer was removed and the aqueous layer was further extracted with 2 additional portions of ethyl acetate. The combined organic layers were washed with brine, dried over magnesium sulfate, filtered and concentrated in vacuo to afford Cap-170a colorless residue. 1H NMR (500 MHz, DMSO-d6) δ ppm 12.65 (1H, br s), 7.44 (1H, d, J=8.24 Hz), 3.77-3.95 (3H, m), 3.54 (3H, s), 3.11-3.26 (2H, m), 1.82-1.95 (1H, m), 1.41-1.55 (2H, m), 1.21-1.39 (2H, m); LC-MS: Anal. Calcd. for [M+H]+ C9H16NO5: 218.1; found 218.1.

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