Реакция #1889

Уравнение реакции

2-amino-5-chloro-α-(2-chlorophenyl)benzyl alcohol

trifluoroacetic acid

sodium hydrogen carbonate

→

crystal

Выход 95.7%

5-chloro-α-(2-chlorophenyl)-2-(trifluoroacetylamino)benzyl alcohol

Выход 95.7%

Растворители

dichloromethane

dichloromethane

Условия реакции

Обработка

1. 1
   ДругоеAfter reaction
2. 2
   Другоеthe organic layer was dried
3. 3
   Другоеafter which the solvent was removed
4. 4
   Другоеthe residue was recrystallized from hexane

Методика

To a solution of 1.0 g of 2-amino-5-chloro-α-(2-chlorophenyl)benzyl alcohol in 12 ml of dichloromethane, a solution of 0.8 g of anhydrous trifluoroacetic acid in 2 ml of dichloromethane was added. After reaction, an aqueous solution of sodium hydrogen carbonate was added, and the organic layer was dried, after which the solvent was removed and the residue was recrystallized from hexane to yield 1.3 g of a crystal.

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