Реакция #1886

Уравнение реакции

water

2-amino-5-chloro-2',4',6'-trimethoxybenzophenone

lithium aluminum hydride

→

crystal

Выход 96.1%

2-amino-5-chloro-α-(2,4,6-trimethoxyphenyl)benzyl alcohol

Выход 96.1%

Растворители

tetrahydrofuran

Условия реакции

Обработка

1. 1
   Экстракцияthe solution was extracted with ethyl acetate
2. 2
   Сушкаdried over anhydrous sodium sulfate
3. 3
   Другоеafter which the solvent was removed

Методика

To a solution of 3.0 g of 2-amino-5-chloro-2',4',6'-trimethoxybenzophenone in 50 ml of tetrahydrofuran, 0.43 g of lithium aluminum hydride was added, followed by stirring for 1 hour. After water was added, the solution was extracted with ethyl acetate and dried over anhydrous sodium sulfate, after which the solvent was removed and the residue was subjected to silica gel column chromatography to yield 2.9 g of a crystal.

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