Реакция #1884995

Уравнение реакции

3,4-di-fluoro-benzaldehyde

malonic acid

piperidine

pyridine

HCl

→

3,4-di-fluoro-cinnamic acid

Выход 95.0%

Условия реакции

Обработка

1. 1
   ТемператураAfter heating it to 80° C.
2. 2
   workup.STIRRINGthe mixture was stirred for 12 hours
3. 3
   ДругоеAfter the reaction
4. 4
   Температураthe resulting solution cooled down to room temperature
5. 5
   ФильтрацияThe resulting powder was filtered
6. 6
   Промывкаwashed with water
7. 7
   Другоеdried in a vacuum oven

Методика

10 g (70.4 mmol) of 3,4-di-fluoro-benzaldehyde, 14.65 g (2 eq.) of malonic acid, and 0.59 g (0.1 eq.) of piperidine were added to 16.7 g (3 eq.) of pyridine and stirred at room temperature for about 1 hour. After heating it to 80° C., the mixture was stirred for 12 hours. After the reaction, the resulting solution cooled down to room temperature and was slowly added with 1M HCl until it was titrated to about pH 4. The resulting powder was filtered and washed with water, and then dried in a vacuum oven. (Yield: 95%)

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