Реакция #1876818

Уравнение реакции

Phosphorus oxychloride

2-hydroxy-4-phenylquinoline

→

2-chloro-4-phenylquinoline

Условия реакции

Обработка

1. 1
   Температураthe mixture was heated
2. 2
   Температураto reflux for 4 hours
3. 3
   workup.ADDITIONthe mixture was added slowly
4. 4
   ЭкстракцияThe mixture was extracted with methylene chloride
5. 5
   Сушкаdried with magnesium sulfate
6. 6
   Фильтрацияfiltered
7. 7
   Концентрированиеconcentrated

Методика

Phosphorus oxychloride (37.4 mL, 402 mmol) was added to 2-hydroxy-4-phenylquinoline and the mixture was heated to reflux for 4 hours. Upon cooling to room temperature, the mixture was added slowly to stirring ice water yielding a white precipitate. The mixture was extracted with methylene chloride, and the organic phases were combined, dried with magnesium sulfate, filtered and concentrated to yield 2-chloro-4-phenylquinoline.

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