Реакция #1876812

Уравнение реакции

Bromine

Compound ( b )

3-ethoxybenzotrifluoride

Water

→

Compound ( c )

Выход 76.9%

2-bromo-5-ethoxybenzotrifluoride

Выход 76.9%

Растворители

ether

Условия реакции

Обработка

1. 1
   Экстракцияthe aqueous layer was extracted three times with ether
2. 2
   Промывкаwashed with saturated aqueous sodium bicarbonate and water
3. 3
   Сушкаdried over anhydrous magnesium sulfate
4. 4
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure

Методика

Bromine (18.2 g) was slowly added dropwise to Compound (b) (19.3 g) at room temperature, and then the mixture was stirred at room temperature for 1 hour. Water and ether were added for liquid separation, and the aqueous layer was extracted three times with ether. The organic layers were combined, washed with saturated aqueous sodium bicarbonate and water, and then dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain 21.0 g of Compound (c).

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