Реакция #1857543

Уравнение реакции

2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-methyloxirane

1,2,4-triazole

sodium hydroxide

→

2-[2-chloro-4-(4-chlorophenoxy)phenyl]-1-(1,2,4-triazol-1-yl)propan-2-ol

Растворители

NMP

Условия реакции

Обработка

1. 1
   ДругоеThe reaction mixture was then partitioned between MTBE and aq. NaHCO3 solution
2. 2
   Экстракцияthe aq. phase was extracted twice with MTBE
3. 3
   ПромывкаThe combined organic phases were washed with water (2×)
4. 4
   Другоеdried
5. 5
   Другоеevaporated
6. 6
   ДругоеThe crude product was crystallized from diisopropyl ether

Методика

A mixture of 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-methyloxirane (109 g), 1,2,4-triazole (27 g) and sodium hydroxide (16 g) in NMP (1 L) was heated to 110° C. for 1 h. The reaction mixture was then partitioned between MTBE and aq. NaHCO3 solution and the aq. phase was extracted twice with MTBE. The combined organic phases were washed with water (2×), dried and evaporated. The crude product was crystallized from diisopropyl ether.

Источник