Реакция #1856346

Уравнение реакции

ester

methyl 2,5-dihydroxybenzoate

3-chlorobenzyl bromide

potassium carbonate

→

2-Carbomethoxy-4-(m-chlorophenylmethyloxy)-phenol

Выход 68.2%

Растворители

acetonitrile

ethyl acetate

Условия реакции

Обработка

1. 1
   Температураunder reflux for 4 hours
2. 2
   Фильтрацияfiltered
3. 3
   ДругоеThe residue was recrystallized from ethanol

Методика

Eight grams (47.62 mmoles) of the above ester was treated with 6.3 ml (47.62 mmoles) of 3-chlorobenzyl bromide and 8 grams potassium carbonate in 70 ml acetonitrile under reflux for 4 hours. The mixture was diluted with 100 ml ethyl acetate, filtered, and stripped in vacuo. The residue was recrystallized from ethanol to give 9.5 g of 2-Carbomethoxy-4-(m-chlorophenylmethyloxy)-phenol (62% yield from 2,5-dihydroxybenzoic acid).

Источник