Реакция #1854

Уравнение реакции

2-bromo-3-benzyloxy-6-hydroxymethylpyridine

potassium acetate

methyl acrylate

→

product

Выход 84.1%

Methyl (3-benzyloxy-6-hydroxymethylpyridin-2-yl)propenoate

Выход 84.1%

Растворители

water

DMF

water

Условия реакции

Обработка

1. 1
   ТемператураThe mixture was cooled
2. 2
   ЭкстракцияThe product was extracted into ethyl acetate (3×30 ml)
3. 3
   ПромывкаThe combined extracts were washed with water (3×25 ml)
4. 4
   Другоеdried
5. 5
   Другоеevaporated
6. 6
   ДругоеThe residue was purified by flash column chromatography
7. 7
   Промывкаeluting with dichloromethane

Методика

To a solution of 2-bromo-3-benzyloxy-6-hydroxymethylpyridine (2.94 g, 10 mmol) in DMF (19 ml) and water (1 ml) were added potassium acetate (2.45 g, 10.0 mmol), tetra-n-butylammonium iodide (3.69 g. 10.0 mmol), bis(triphenyl-phosphine)palladium dichloride (281 mg, 0.4 mmol) and methyl acrylate (2.70 ml. 2.58 g, 30 mmol). The mixture was placed under nitrogen and stirred and heated at 120° C. for 5 h. The mixture was cooled and added to water (180 ml). The product was extracted into ethyl acetate (3×30 ml). The combined extracts were washed with water (3×25 ml), dried and evaporated. The residue was purified by flash column chromatography eluting with dichloromethane, then 4:1 dichloromethane:ethyl acetate to give the product (2.516 g, 84%).

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