Реакция #1852

Уравнение реакции

3-benzyloxy-6-hydroxymethyl-2-iodopyridine

potassium acetate

ethyl acrylate

→

solution

Выход 62.0%

Ethyl (3-benzyloxy-6-hydroxymethylpyridin-2-yl)propenoate

Выход 62.0%

Растворители

DMF

water

Условия реакции

Методика

To a solution of 3-benzyloxy-6-hydroxymethyl-2-iodopyridine (1.20 g, 3.50 mmol) in DMF (6.4 ml) and water (0.32 ml) were added potassium acetate (0.83 g, 8.5 mmol) palladium acetate (32 mg, 0.14 mmol) and ethyl acrylate (1.1 ml, 1.01 g, 10 mmol). The mixture was placed under nitrogen and stirred and heated at 120° C. for 1.25 h. By hplc the solution yield was 62%.

Источник