Реакция #1847719

Уравнение реакции

4-chloro-2-(4-chlorophenyl)-6-isopropylpyrimidine

4-amino-2,2,6,6-tetramethylpiperidine

→

2-(4-Chlorophenyl)-6isopropyl-4-((2,2,6,6-tetramethylpiperidin-4-yl)amino)-pyrimidine dihydrochloride

Растворители

water

Условия реакции

Обработка

1. 1
   ТемператураAfter cooling
2. 2
   workup.STIRRINGthe mixture was stirred at room temperature
3. 3
   ФильтрацияThe white precipitate was filtered off with suction
4. 4
   Другоеdried in vacuo
5. 5
   workup.ADDITIONBy addition of hydrogen chloride
6. 6
   Другоеthe title compound was precipitated
7. 7
   Фильтрацияfiltered off with suction
8. 8
   Другоеdried in vacuo

Методика

A mixture of 534 mg of 4-chloro-2-(4-chlorophenyl)-6-isopropylpyrimidine and 1.8 g of 4-amino-2,2,6,6-tetramethylpiperidine was heated at 150° C. for 2 hours with stirring. After cooling, 20 ml of water were added and the mixture was stirred at room temperature. The white precipitate was filtered off with suction, dried in vacuo and taken up in 20 ml of ethyl acetate. By addition of hydrogen chloride, the title compound was precipitated, filtered off with suction and dried in vacuo. Yield: 0.8 g.

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