Реакция #1846

Уравнение реакции

4-bromoanisole

Magnesium

iodine

THF

1,2-dibromoethane

→

Anisylmagnesium Bromide

Условия реакции

Обработка

1. 1
   Температураat reflux for 15 min
2. 2
   workup.STIRRINGstirring
3. 3
   ДругоеAfter an exothermic reaction
4. 4
   workup.STIRRINGstirring
5. 5
   Другоеwas accompanied by a rise in temperature to 35° C
6. 6
   ТемператураThe mixture was cooled to 20° C.
7. 7
   Температураwith cooling
8. 8
   workup.STIRRINGStirring
9. 9
   workup.ADDITIONafter the addition

Методика

Magnesium (36 g, 1.5 mol), iodine (a few crystals) and THF (1 L) were heated under nitrogen, with stirring, at reflux for 15 min. The mixture was cooled to 20° C., stirring stopped, and 1,2-dibromoethane (2.5 ml) added. After an exothermic reaction was observed (a few min) stirring was restarted which was accompanied by a rise in temperature to 35° C. The mixture was cooled to 20° C. and 4-bromoanisole slowly added over 1 h at 14°-18° C. with cooling. Stirring was continued for 10 min after the addition was complete.

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