Реакция #1842895

Уравнение реакции

2-methyl-l-naphthol

aluminum chloride

acetyl chloride

→

2-methyl-4-acetyl-1-naphthol

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   workup.ADDITIONwas slowly added
2. 2
   Другоеreaction
3. 3
   workup.STIRRINGThe reaction mixture was stirred at 10° C. or below for 1 h
4. 4
   ЭкстракцияThen, the reaction product was extracted with dichloromethane
5. 5
   Промывкаthe extracted layer was washed with water
6. 6
   СушкаFurther, the extracted layer was dried over anhydrous sodium sulfate
7. 7
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure
8. 8
   ДругоеThe residue was recrystallized with benzene

Методика

To an ice-cooled solution of 2-methyl-l-naphthol (7.9 g, 0.05 mmol) in dichloromethane, anhydrous aluminum chloride (7.2 g) was slowly added with stirring, followed by slow addition of acetyl chloride (4.7 g) to start reaction. The reaction mixture was stirred at 10° C. or below for 1 h, then at room temperature for 3 h. Thereafter, the mixture was poured into ice water. Then, the reaction product was extracted with dichloromethane and the extracted layer was washed with water. Further, the extracted layer was dried over anhydrous sodium sulfate and the solvent was distilled off under reduced pressure. The residue was recrystallized with benzene, giving the desired compound, 2-methyl-4-acetyl-1-naphthol, in an amount of 3.9 g .

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