Реакция #1835100

Уравнение реакции

sodium carbonate

4-(cyclohexyloxy)phenylboronic acid

3-bromo-5-chloropyridin-2-amine

→

title compound

Выход 48.4%

5-chloro-3-[4-(cyclohexyloxy)phenyl]pyridin-2-amine

Выход 48.4%

Растворители

DME

water

Условия реакции

Обработка

1. 1
   workup.ADDITIONSilica gel was added
2. 2
   Концентрированиеthe mixture was concentrated in vacuo
3. 3
   ДругоеThe residue was purified by column chromatography (silica gel, eluted with EtOAc in hexane)

Методика

A mixture of sodium carbonate (307 mg), tetrakis(triphenylphosphine)palladium(0) (50.1 mg), 4-(cyclohexyloxy)phenylboronic acid (414 mg) and 3-bromo-5-chloropyridin-2-amine (300 mg) in DME (15 mL) and water (3 mL) was stirred at 80° C. for 5 hr. Silica gel was added and the mixture was concentrated in vacuo. The residue was purified by column chromatography (silica gel, eluted with EtOAc in hexane) to give the title compound (212 mg) as a yellow gum.

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