Реакция #1833227

Уравнение реакции

3,5-Difluoro-2-methoxyphenol

boron tribromide

→

title compound

3,5-Difluorobenzene-1,2-diol

Растворители

dichloromethane

dichloromethane

Условия реакции

Обработка

1. 1
   ДругоеThe cooling bath was removed
2. 2
   ТемператураThe mixture was cooled to −30° C.
3. 3
   workup.ADDITIONtreated in portions with water (3 mL)
4. 4
   Температураwarmed to 20° C
5. 5
   workup.ADDITION6 M HCl (10 mL) and ethyl acetate (30 mL) were added
6. 6
   workup.STIRRINGthe mixture was stirred for 20 min
7. 7
   Другоеto produce two clear phases
8. 8
   ЭкстракцияThe aqueous phase was extracted with ethyl acetate (20 mL)
9. 9
   Промывкаthe combined organic phases were washed with saturated NaCl (10 mL)
10. 10
    Сушкаdried (Na2SO4)
11. 11
    Другоеrotary evaporated

Методика

3,5-Difluoro-2-methoxyphenol (1.0 g, 6.3 mmol, prepared as described in Jones, Lyn H.; Randall, Amy; Barba, Oscar; Selby, Matthew D., Organic & Biomolecular Chemistry 2007, 5, 3431-3433) was dissolved in dry dichloromethane (11 mL), cooled to −20 to −30° C. and treated in portions with boron tribromide (BBr3) solution in dichloromethane (1.0 M; 13 mL, 13 mmol). The cooling bath was removed and the mixture was stirred for 20 h at 20° C. The mixture was cooled to −30° C., treated in portions with water (3 mL) and then warmed to 20° C. 6 M HCl (10 mL) and ethyl acetate (30 mL) were added, and the mixture was stirred for 20 min to produce two clear phases. The aqueous phase was extracted with ethyl acetate (20 mL), and the combined organic phases were washed with saturated NaCl (10 mL), dried (Na2SO4) and rotary evaporated to give the title compound as an oil which solidified upon standing (720 mg, 78%): 1H NMR (400 MHz, CDCl3) δ 6.51 (ddd, J=9.5, 2.8, 2.1 Hz, 1H), 6.45 (ddd, J=10.3, 8.7, 2.9 Hz, 1H), 5.71 (s, 1H), 5.06 (s, 1H); 19F NMR (376 MHz, CDCl3) δ −119.56, −136.16; EIMS m/z 146.

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