Реакция #1829970

Уравнение реакции

trans-4-pentylcyclohexylcyclohexenone

hydrochloric acid

magnesium

p-dibromobenzene

diethyl ether

→

1-(trans-4-pentylcyclohexyl)-4-(4-bromophenyl)-4-hydroxycyclohexene

Условия реакции

Обработка

1. 1
   Другоеwas formed
2. 2
   Другоеwere reacted at room temperature for additional 1 hour
3. 3
   workup.ADDITIONwas added dropwise to the reaction mixture
4. 4
   Экстракцияfollowed by the extraction of the reaction mixture with diethyl ether
5. 5
   ПромывкаAfter the extract was washed with saturated NaCl, anhydrous sodium sulfate
6. 6
   workup.ADDITIONwas added
7. 7
   Другоеto dry the extract
8. 8
   workup.DISTILLATIONThe diethyl ether was distilled off under reduced pressure

Методика

A solution of 7.2 g of p-dibromobenzene in 40 ml of anhydrous diethyl ether was added dropwise under stirring at 10°-15° C. to 0.66 g of magnesium metal powder, followed by reaction at room temperature for one hour so that a Grignard reagent was formed. After 5 g of trans-4-pentylcyclohexylcyclohexenone were added under stirring at -10 ° to 0° C. to the thus-formed Grignard reagent, they were reacted at room temperature for additional 1 hour. After the completion of the reaction, diluted hydrochloric acid was added dropwise to the reaction mixture, followed by the extraction of the reaction mixture with diethyl ether. After the extract was washed with saturated NaCl, anhydrous sodium sulfate was added to dry the extract. The diethyl ether was distilled off under reduced pressure, whereby 1-(trans-4-pentylcyclohexyl)-4-(4-bromophenyl)-4-hydroxycyclohexene was obtained as a crude reaction product.

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