Реакция #1806341

Уравнение реакции

Cystamine

2-nitroamino-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone

→

2-[5-(3-pyridylmethyl)-4-oxo-2-pyrimidylamino]ethyl disulphide

Растворители

ethanol

Условия реакции

Методика

Cystamine is reacted with 2-nitroamino-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone by heating in ethanol to give 2-[5-(3-pyridylmethyl)-4-oxo-2-pyrimidylamino]ethyl disulphide which is reduced with dithiothreitol to give 2-(2-mercaptoethylamino)-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone which is reacted with 5-dimethylaminomethyl-2-furylmethanol in cold aqueous hydrochloric acid to give 2-[2-(5-dimethylaminomethyl-2-furylmethylthio)ethylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone.

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